SD microdosing - a repeated dosing study

Completed

Conditions: subjectieve effecten, cognitief functioneren
Performance and mood enhancement in society

Registration Number: NL-OMON55178

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

* Proficient knowledge of the English language
* Written Informed Consent
* Understanding the procedures and the risks associated with the study.
* Age between 18 and 65 years
* Absence of any major medical condition as determined by medical examination
and laboratory analysis
* Absence of any major psychological condition as determined by medical
examination
* Free from psychotropic medication
* Participants must be willing to refrain from taking illicit psychoactive
substances during the study.
* Participants must be willing to drink only alcohol-free liquids and no
coffee, black or green tea, or energy drink after midnight of the evening
before the study session, as well as during the study day.
* Participants must be willing not to drive a traffic vehicle or to operate
machines within 24 h after substance administration.
* Normal weight , body mass index (weight/height2) between 18 and 28 kg/m2

Exclusion Criteria

* Having used a psychedelic substance (regular dose) such as LSD, psilocybin,
ayahuasca, DMT, Salvinorin, Mescaline, MDMA, NBOMe, 2Cs or any other
psychedelic drug within the past 3 months.
* History of drug addiction (determined by the medical questionnaire, drug
questionnaire and medical examination)
* Previous experience of serious side effects to psychedelic drugs (anxiety or
panic attacks)
* Pregnancy or lactation
* Hypertension (diastolic > 90 mmHg; systolic > 160 mmHg)
* Current or history of psychiatric disorder (determined by the medical
questionnaire and medical examination)
* Psychotic disorder in first-degree relatives
* Any chronic or acute medical condition
* History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)
* For women: no use of a reliable contraceptive
* Tobacco smoking (>20 per day)
* Excessive drinking (>20 alcoholic consumptions per week)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective is to examine the possible positive mood and positive<br /><br>subjective effects following repeated doses of 15 mcg LSD compared to placebo. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objective is to examine the possible induced cognitive<br /><br>performance and increase in neuroplasticity following repeated doses of 15 mcg<br /><br>LSD compared to placebo. </p><br>