SD microdosing - a dose finding study

Completed

Conditions: subjective effects, cognitive functioning
Performance and mood enhancement in society

Registration Number: NL-OMON46425

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 27

Inclusion Criteria

* Previous experience with a psychedelic drug, but not within the past 3 months.
* Proficient knowledge of the English language
* Written Informed Consent
* Understanding the procedures and the risks associated with the study.
* Age between 18 and 40 years
* Absence of any major medical condition as determined by medical examination and laboratory analysis
* Absence of any major psychological condition as determined by medical examination
* Free from psychotropic medication
* Participants must be willing to refrain from taking illicit psychoactive substances during the study.
* Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day.
* Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.
* Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2

Exclusion Criteria

* History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination)
* Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks)
* Pregnancy or lactation
* Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg)
* Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)
* Psychotic disorder in first-degree relatives
* Any chronic or acute medical condition
* History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)
* For women: no use of a reliable contraceptive
* Tobacco smoking (>20 per day)
* Excessive drinking (>20 alcoholic consumptions per week)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study hypothesis is that higher doses of LSD will be associated with<br /><br>increasingly greater and potentially also qualitatively different subjective<br /><br>effects compared to placebo. An additional study parameter is the change in<br /><br>cognitive performance under the influence of LSD compared to placebo.</p><br>

Secondary Outcome Measures