Comparison of Quality of Recovery (QoR)-15 Scores According to the Anesthetics (Desflurane vs. Remimazolam) in the Patients With Lumbar Fusion Surgery: a Prospective Double-blind Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Desflurane
- Conditions
- Lumbar Fusion Surgery
- Sponsor
- Gangnam Severance Hospital
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- The difference of QoR-15 scores
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of the study is to compare the quality of recovery (QoR)-15 scores according to the use of maintenance anesthetics in the lumbar fusion surgery. Total intravenous anesthesia (TIVA) have been known to help reducing risks of postoperative nausea/vomiting and malignant hyperthermia. However, it is still not enough to explain which is better between TIVA or inhalation anesthesia. In particular, there is no study to investigate overall postoperative functional recovery via QoR-15 in patients receiving TIVA with remimazolam. The hypothesis of our study is that total intravenous anesthesia based on remimazolam will demonstrate better quality of recovery compared with the anesthesia based on inhalation using desflurane.
Investigators
Myoung Hwa Kim
Associate Professor
Gangnam Severance Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult patients who aged 20-70 years with ASA-PS 1-3, BMI \<30 undergoing lumbar fusion surgery under general anesthesia
Exclusion Criteria
- •Tolerance or hypersensitivity to benzodiazepine or propofol
- •Dependence or addiction to psychotropic drugs or alcohol
- •Pregnant women
- •subjects who lack the ability to make decisions and susceptible to voluntary participation decisions
Arms & Interventions
Desflurane group
General anesthesia with volatile agent of desflurane
Intervention: Desflurane
Remimazolam group
Remimazolam group will be started with remiamazolam at 6 mg/kg/h and TCI Minto model of remifentanil for the time of anesthesia induction, and maintained at 0.5-1.5 mg/kg/h.
Intervention: Remimazolam
Outcomes
Primary Outcomes
The difference of QoR-15 scores
Time Frame: postoperative day 1
The difference of scores in the Quality of Recovery (QoR)-15 survey between desflurane group and remimazolam group. 0 (minimum), 150 (maximum): Higher scores means better.