A Randomized control trial comparing three different group of drugs which can better decrease stress response to putting a tube in patients trachea for proper lung ventilation during general anaesthesia in laparoscopic surgery.
Phase 4
- Conditions
- Health Condition 1: - Health Condition 2: - Health Condition 3: K802- Calculus of gallbladder without cholecystitis
- Registration Number
- CTRI/2024/02/062361
- Lead Sponsor
- SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1)American society of anaesthesiologist grade 1 and 2 patients.
2)Patients undergoing elective laparoscopic surgeries.
Exclusion Criteria
1)patients refusal
2)Heart rate <60/min
3)systolic blood pressure of <100mmhg
4)Mallampatti grading 3 and 4
5) anticipated difficult intubation.
6)patients with systemic disorders like Left ventricular failure,any degree of heart block,ischemic heart disease,aortic stenosis and bronchial asthama.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To monitor change in heart rate during laryngoscopy and endotracheal intubation,and which drug is the best in blunting hemodynamic stress response during endotracheal intubation.Timepoint: T0:Base line HR,BP,Spo2 <br/ ><br>T1:After induction <br/ ><br>T2:Before laryngoscopy <br/ ><br>T3:Immediately after laryngoscopy and intubation <br/ ><br>T4:2 mins after intubation <br/ ><br>T5:5mins after intubation <br/ ><br>T6:Before pneumoperitoneum <br/ ><br>T7:2mins after pneumoperitoneum <br/ ><br>T8:5mins after pneumoperitoneum <br/ ><br>T9:10mins after pneumoperitoneum <br/ ><br>T10 :Before intubation <br/ ><br>T11:Immediately after extubation. <br/ ><br>T12:5mins after extubation.
- Secondary Outcome Measures
Name Time Method 1)To monitor change in blood pressure during laryngoscopy and intubation. <br/ ><br>2)Requirement of analgesic supplementation intraoperatively. <br/ ><br>3)Level of sedation at the time of extubationTimepoint: Be will also be recorded along with heart rate. <br/ ><br>Every 30 mins post intubation . <br/ ><br>Level of sedation at the time of extubation will be assessed with the help of riker sedation agitation scale.