Brain Imaging of chronic and acute aphasia in Aache

Recruiting

Conditions: R47.0
Dysphasia and aphasia

Registration Number: DRKS00031980

Lead Sponsor: Klinik für Neurologie der Uniklinik RWTH Aachen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 29

Inclusion Criteria

Native speaker level in German (for patients prior to stroke)

For patients:
- Etiology: first stroke
- Phase of disease: subacute or chronic phase (at least 6 weeks after stroke)
- Presence of aphasia/ residual aphasia
- Capacity to consent
- Treatment at the Aachen aphasia ward at the time of participation in the study

Exclusion Criteria

- Active implants
- Intracorporal metal which can harm the patient by movement or heating
- Dentures with magnetic parts
- Implant in head which leads to severe artifacts
- MR-safe passive implants (e.g., artificial knee or hip) without valid document
- Claustrophobia
- Pregnancy
- Other independent neurological diseases which lead to language disorders, particularly dementia and severe microangiopathies
- Uncontrolled epilepsy

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Data from Magnetic Resonance Imaging (MRI, structural [T1, FLAIR, DTI] and functional [resting state und task-related fMRI]) at the beginning and at the end of 6 weeks intensive speech and language therapy (pre-post-design), adjusted for relevant covariables.

Secondary Outcome Measures

Name	Time	Method
Behavioral data are collected from clinical routine. Different tests are conducted depending on the type and severity of aphasia and possible concomitant disorders. The tests are either carried out at T1 and T2 or once during the stay. In particular, they include language tests (Aachen Aphasia Test - AAT, Lexikon Modellorientiert - LeMo, Bielefelder Wortfindungsscreening - BIWOS, Regensburger Wortflüssigkeitstest - RWT, Nonverbalen Semantiktest - NVST, Wortproduktionsprüfung - WPP, Hierarchische Wortlisten - HWL, Szenario-Test, spontaneous speech from picture description) and neuropsychological tests (Testbatterie zur Aufmerksamkeitsprüfung - TAP, Leistungsprüfsystem - LPS, Nonverbalen Lerntest - NVLT, Corsi Block Tapping Test - CORSI, Wechsler Adult Intelligence Scale - WAIS IV).