Evaluation of the Role of Power Doppler Sonography in the Diagnosis of Hemophilic Joint Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Inherited Bleeding Disorders
- Sponsor
- New York Presbyterian Hospital
- Enrollment
- 43
- Locations
- 1
- Primary Endpoint
- Comparison of magnetic resonance imaging (MRI) and power Doppler sonograms on patients with target joint
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to see whether power Doppler sonography (PDS) can be used to diagnose synovitis in patients with inherited bleeding disorders.
Detailed Description
Aim #1 - To determine if PDS can be used to diagnose synovial hypertrophy and inflammation in joint disease associated with inherited bleeding disorders. MRI will be used as a reference standard. Aim #2 - To determine if PDS can be used to assess therapeutic response to treatment. Aim #3 - To determine if PDS can be used as a screening tool for diagnosing early synovitis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of inherited bleeding disorder
- •Age of at least 6 years
- •History of at least 4 bleeds in the same joint in the preceding 6 months
- •Joint swelling, synovitis or deformity
- •Meet inclusion criteria for Aim 1 and will be having a synovectomy
- •Age of at least 1 year
- •Have had at least 2 joint bleeds
Exclusion Criteria
- •Not meeting inclusion criteria
Outcomes
Primary Outcomes
Comparison of magnetic resonance imaging (MRI) and power Doppler sonograms on patients with target joint
Time Frame: Up to 1 month
Evaluation of PDS on patients with target joints pre and post synovectomy to assess response to therapeutic intervention
Time Frame: 1. day of synovectomy; 2. 6 months post synovectomy.
Evaluation of PDS on patients with at least 2 joint bleeds to diagnose early synovitis
Time Frame: 1 day