Evaluation of the Role of Power Doppler Sonography in the Diagnosis of Hemophilic Joint Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Comparison of magnetic resonance imaging (MRI) and power Doppler sonograms on patients with target joint
研究概览
简要总结
The purpose of this study is to see whether power Doppler sonography (PDS) can be used to diagnose synovitis in patients with inherited bleeding disorders.
详细描述
Aim #1 - To determine if PDS can be used to diagnose synovial hypertrophy and inflammation in joint disease associated with inherited bleeding disorders. MRI will be used as a reference standard.
Aim #2 - To determine if PDS can be used to assess therapeutic response to treatment.
Aim #3 - To determine if PDS can be used as a screening tool for diagnosing early synovitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 1 Year 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of inherited bleeding disorder
- •Age of at least 6 years
- •History of at least 4 bleeds in the same joint in the preceding 6 months
- •Joint swelling, synovitis or deformity
- •Meet inclusion criteria for Aim 1 and will be having a synovectomy
- •Age of at least 1 year
- •Have had at least 2 joint bleeds
排除标准
- •Not meeting inclusion criteria
结局指标
主要结局
Comparison of magnetic resonance imaging (MRI) and power Doppler sonograms on patients with target joint
时间窗: Up to 1 month
Evaluation of PDS on patients with target joints pre and post synovectomy to assess response to therapeutic intervention
时间窗: 1. day of synovectomy; 2. 6 months post synovectomy.
Evaluation of PDS on patients with at least 2 joint bleeds to diagnose early synovitis
时间窗: 1 day
次要结局
未报告次要终点