跳至主要内容
临床试验/NCT00794404
NCT00794404已完成不适用

Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy

Dr Maria-Atonietta D'AGOSTINO6 个研究点 分布在 1 个国家目标入组 489 人开始时间: 2004年12月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
489
试验地点
6

研究概览

简要总结

The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis

详细描述

Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients < 50 years old, consulting for spinal inflammatory symptoms > 3 months duration
  • patients consulting for arthritis or tenderness joints > 3 months duration
  • patients < 50 years old consulting for enthesitis or dactylitis > 3 months duration
  • patients with uveitis and HLA-B27 positivity
  • relatives of SpA patients consulting for symptoms suggestive of SpA

排除标准

  • patient with confirmed diagnosis of rheumatic disease (included SpA)
  • patient protected by law (patient <18 years old, pregnant woman)
  • patient who can't atempt the RMI
  • patient who will have difficulties to complete the two years of follow-up

研究者

发起方
Dr Maria-Atonietta D'AGOSTINO
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Dr Maria-Atonietta D'AGOSTINO

PU-PH

Groupe Français d'Etude Génétique des Spondylarthropathies

研究点 (6)

Loading locations...

相似试验