Comparison of propofol and ketofol on motor evoked potentials in patients undergoing thoracic and lumbar spine surgery.
Not Applicable
- Conditions
- Health Condition 1: null- Patients between age group 18-65 years posted for thoracolumbar spine surgery
- Registration Number
- CTRI/2018/09/015768
- Lead Sponsor
- All India Institute of Medical Sciences AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients posted for thoracolumbar spine surgery and planned for transcranial motor evoked potential monitoring
Exclusion Criteria
Patients with preoperative motor power <3,
pre-existing myopathies,
morbid obesity,
history of coronary artery disease,
history of chronic renal and hepatic insufficiency,
history of allergy to any of the study medications,
history of seizures and
history of psychiatric disease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effect of propofol and ketofol on amplitudes and latencies of TcMEPs, when these agents are used with fentanyl for the maintenance of anaesthesia during thoracolumbar spine surgeryTimepoint: Following induction of anesthesia and after obtaining threshold voltage, MEPs will be used for recording amplitude and latency at every thirty minutes interval for first two hours T1 (30 mins), T2 (60 minutes), T3 (90 minutes) and T4 (120 minutes). The values will be recorded hourly thereafter till the end of surgery
- Secondary Outcome Measures
Name Time Method To compare haemodynamic parameters between the two anaesthetic regimens. <br/ ><br>Timepoint: Hemodynamic parameters will be recorded every thirty minutes interval for first two hours T1 (30 mins), T2 (60 minutes), T3 (90 minutes) and T4 (120 minutes). The values will be recorded hourly thereafter till the end of surgery