To Compare the effectivness of Propofol and Ketofol in patients undergoing Spinal surgery under General Anaesthesia
Not Applicable
- Conditions
- Health Condition 1: M249- Joint derangement, unspecified
- Registration Number
- CTRI/2024/02/062780
- Lead Sponsor
- Institute of Neurosciences Kolkata
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Aged 18–65 years
2. Either gender
3. ASA grade I and II
4. Scheduled for elective spinal instrumentation surgeries under TIVA
Exclusion Criteria
Patient refusal.
2. Patients with hypersensitivity to any of the study drugs
3. Patients with BMI >30 kg/m2 4.ASA grade > II
5. Patients with significant cardiac disease, COPD and restrictive lung disease 6. Patients with significant renal or hepatic impairment
7. Patients with CV junction anomalies and all cervical spinal procedures
8. Redo surgery
9. Deformity corrective surgeries ( like scoliosis) 10. Patients on medications for chronic pain.
11. Patients with neuropsychiatric disorders
12. Duration of surgery more than 4 hours
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate and compare intra and post-operative hemodynamic effects of ketofol infusion versus propofol infusion in patients undergoing spinal instrumentation procedures under total <br/ ><br> intravenous anaesthesia [TIVATimepoint: Before induction <br/ ><br>Post intubation at 1 min <br/ ><br>On incision <br/ ><br>15 min <br/ ><br>30 min <br/ ><br>45 min <br/ ><br>1 hr <br/ ><br>1 hr 15 min <br/ ><br>1 hr 30 min <br/ ><br>1 hr 45 min <br/ ><br>2 hr <br/ ><br>2 hr 15 min <br/ ><br>2 hr 30 min <br/ ><br>2 hr 45 min <br/ ><br>3 hr <br/ ><br>3 hr 15 min <br/ ><br>3 hr 30 min <br/ ><br>3 hr 45 min <br/ ><br>4 hr <br/ ><br>At extubation <br/ ><br>1 hr post operative <br/ ><br>2 hr post operative <br/ ><br>4 hr post operative
- Secondary Outcome Measures
Name Time Method Compare the total amount of propofol consumptionTimepoint: In the intraoperative period;Evaluate and compare the awakening timeTimepoint: During extuabtion;Incidence of PONVTimepoint: In the postoperative period;Postoperative analgesia requirementTimepoint: In the postoperative period;Requirements of rescue analgesiaTimepoint: In the postoperative period