Intravenous Lidocaine and Acute Rehabilitation

Phase 4

Completed

• Conditions: Pain, Postoperative; Opioid Consumption, Postoperative; Postoperative Fatigue

• Registration Number: NCT00330941
• Lead Sponsor: The Cleveland Clinic

Brief Summary

Background: Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function. The investigators therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization.

Methods: Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg.kg-1 lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg-1.h-1 intraoperatively and 1.33 mg.kg-1.h-1 for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leucocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (median \[25%-75% interquartile range\] Saline vs Lidocaine groups) were analyzed using Mann-Whitney tests. P\<0.05 was considered statistically significant.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01
• Study Completion: 2004-12
• Study First Submitted: 2006-05-25
• Study First Submitted QC: 2006-05-25
• Study First Posted: 2006-05-29
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-12
• Last Update Posted: 2023-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• ASA I-III
• non-malignant disease

Exclusion Criteria

• greater than 70 years
• history of gastro-duodenal peptic ulcer or renal failure (contraindications to the use of nonsteroidal anti-inflammatory drug)
• hepatic insufficiency
• psychiatric disorder
• steroid treatment
• chronic treatment with opioid

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Sevoflurane consumption
Pain scores
abdominal comfort
fatigue scores

Secondary Outcome Measures

Name	Time	Method
hospital stay
endocrine and metabolic responses
bowel function

Trial Locations

Locations (1)

CHU de Liège, University of Liège; 🇧🇪 Liege, Belgium