Preemptive Analgesia for Postlaminectomy

Phase 4

Completed

• Conditions: Laminectomy
• Interventions: Drug: Lidocaine, perineural injection, intraoperatively; Drug: Lidocaine

• Registration Number: NCT00656526
• Lead Sponsor: Harran University

Brief Summary

To relieve post laminectomy pain, we have tried intraoperative perineural injection of lidocaine right after the exposure in expecting that this would be preemptive analgesia by blocking the nerve transmission so that postoperative pain starts later and lighter.

Detailed Description

A randomized double-blind 40 patients aged 18-50 of ASA I and II undergoing laminectomy were included in the study. All the patients were followed for their heart rate, arterial pressure , respiratory rate, oxygen saturation, end tidal CO2 and postoperative VAS scores.

All the patients were premedicated with midazolam 0.1 mg/kg intramuscularly 40 minutes prior to surgery. The induction was made 2 mg/kg propofol, 1 ug/kg remifentanyl, 0.5mg/kg rocuronium. After the orotracheal intubation anesthesia was maintained with isoflurane (%0.5-2.0) and 0.1 mg/kg rocuronium.Just before the exposure of dorsal root, 0.5 cc %2 lidocaine was injected on the dorsal root.The patients postoperative analgesic period, VAS scores and additional analgesic need was recorded. For the postoperative analgesia tramadol 1 mg/kg tramadol was used.

Study Timeline

• Study Start: 2007-09
• Primary Completion: 2007-11
• Study Completion: 2007-12
• Status Verified: 2008-04
• Study First Submitted: 2008-04-07
• Study First Submitted QC: 2008-04-10
• Last Update Submitted: 2008-04-10
• Study First Posted: 2008-04-11
• Last Update Posted: 2008-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• laminectomy
• 18-50 age
• ASA 1-2
• both sex

Exclusion Criteria

• under 18 or older than 50
• any disease other than back pain\
• ASA 3-4

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A01L	Lidocaine, perineural injection, intraoperatively	-
A01L	Lidocaine	-

Primary Outcome Measures

Name	Time	Method
In the laminectomy operation, right after the exposure of the dorsal root , an injection of lidocaine attenuates postoperative pain.	postoperative 24 hours

Trial Locations

Locations (1)

harran University Education, Research and application hospital; 🇹🇷 Sanliurfa, Turkey