Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

Not Applicable

Completed

• Conditions: Penicillin Allergy
• Interventions: Procedure: Immediate skin test

• Registration Number: NCT00789217
• Lead Sponsor: Chulalongkorn University

Brief Summary

This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.

Detailed Description

The results of skin test with immediate reading will be compared between alkali-treated penicillin G and DAP reagents from Diater

Study Timeline

• Study First Submitted: 2008-11-07
• Study First Submitted QC: 2008-11-07
• Study First Posted: 2008-11-11
• Study Start: 2008-12
• Primary Completion: 2010-03
• Study Completion: 2010-08
• Status Verified: 2010-11
• Last Update Submitted: 2010-11-26
• Last Update Posted: 2010-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

1. Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins
2. 15-65 years of age

Exclusion Criteria

1. On antihistamine/ cannot discontinue antihistamine before the test
2. Having asthma exacerbation
3. Being pregnant
4. Suffering from severe systemic disease/ in bad health

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Penicillin G Sodium	Immediate skin test	Penicillin G Sodium from routine clinical use
In-house penicillin testing preparation	Immediate skin test	In-house penicillin testing prepared from alkali-treated penicillin G
Commercial penicillin test kit	Immediate skin test	Commercial penicillin test kit order from Diater company

Primary Outcome Measures

Name	Time	Method
The skin testing results of in-house penicillin skin test and Penicillin G Sodium compared to commercial penicillin testing kit	1 year

Secondary Outcome Measures

Name	Time	Method
Clinical correlation and side effects	1 year
Correlations between Penicillin skin test result with specific IgE and/or basophil activation test	1 year

Trial Locations

Locations (1)

Faculty of Medicine, Chulalongkorn University; 🇹🇭 Bangkok, Thailand