Development and Validation of an Enhanced Prediction Score for Post-operative Acute Renal Failure Following Liver Resection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Renal Failure
- Sponsor
- University of Zurich
- Enrollment
- 549
- Locations
- 1
- Primary Endpoint
- Development of an enhanced prediction score for ARF
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF following hepatic surgery. This prediction score allows early identification of patients at high risk of ARF and may support decision-making for protective kidney treatment.
Detailed Description
To enhance and validate an already pre-existing score accurately predicting post-operative acute renal failure (ARF) after hepatic surgery We will enhance a pre-existing score predicting ARF based on pre-operative as well as intra-operative predictors. Development process: we will identify the strongest predictors of ARF in a multivariable logistic regression model followed by a stepwise backward logistic regression analysis and bootstrapping. Validation process: we will perform an internal validation by calibrating the prediction model as well as by k-fold cross validation (c statistics) and bootstrapping. Additionally, we will calculate the discrimination by the area under the curve (AUC). Decision curve analysis: Furthermore we will perform a decision curve analysis to evaluate the clinical consequences of both prediction scores whether a patient with increased ARF risk would post-operative benefit of a treatment on the ICU.
Investigators
Ksenija Slankamenac
Md PhD
University of Zurich
Eligibility Criteria
Inclusion Criteria
- •\> 18 years
- •scheduled for liver surgery
- •benign as well as malignant diseases
Exclusion Criteria
- •liver trauma
- •incomplete data sets
- •pre-operative chronic renal failure requiring hemodialysis
Outcomes
Primary Outcomes
Development of an enhanced prediction score for ARF
Time Frame: within 48 hours post-operative
Development of an enhanced but still simple and easy applicable score based on pre- and extended by intra-operative risk factors to predict postoperative ARF in patients scheduled for liver resection
Secondary Outcomes
- Decision curve analysis(within 48 hours post-operative)
- internal validation of the enhanced prediction score(within 48 hours post-operative)