Effects of dl-methylephedrine on dopamine transporter in healthy adulgs using PET: randomized, placebo-controlled, double-blind, comparative study
Not Applicable
- Conditions
- healthy adults
- Registration Number
- JPRN-UMIN000034612
- Lead Sponsor
- ippon Medical School
- Brief Summary
There was no significant difference in the average change rate of DAT-BP between the two groups in both caudate (4.4% for methylephedrine group and -1.2% for placebo group) and putamen (3.6% for methylephedrine group and 0.5% for placebo group).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
Subjects with drug allergy. Subjects taking drugs within 2 weeks of the trial. Subjects with hyperthyroidism, hypertension, heart disease, diabetes, severe asthma or hypoxemia. Subject who is contraindicated for the use of MRI. Subject without the history of smoking. Subject who are judged as not suitable for participation in this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method binding potential of dopamine transporter 2 hours after administration of dl-methylephedrine
- Secondary Outcome Measures
Name Time Method blood and/or urine concentration, MRI