Study on the clinical effecy and mechanism of KaiyuTongzhi method in treating metabolic syndrome
- Conditions
- metabolic syndrome
- Registration Number
- ITMCTR2022000029
- Lead Sponsor
- Guang'anmen Hosptial
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Age 18-60 years old, gender is not limited;
(2) Central obesity: waist circumference male = 90cm, female = 85cm;
(3) Hyperglycemia: fasting blood glucose = 6.1 mmol/L or 2 h after sugar load blood glucose = 7.8 mmol/L and/or those who have been diagnosed with diabetes and treated;
(4) Hypertension: blood pressure = 130/85 mmHg (1 mmHg = 0.133 kPa) and /or has been confirmed as hypertension and treated;
(5) Fasting triglycerides (TG) = 1.70 mmol/L;
(6) Fasting HDL cholesterol (HDL-C) < 1.04 mmol/L;
(7) The TCM syndrome classification are hepatic depression stagnation and syndrome of intermingled phlegm and blood stasis.
(3)(4)(5)(6) is diagnostic with two or more items.
(1) Patients with serious complications of type 2 diabetes mellitus (such as diabetic nephropathy, diabetic foot, diabetic ketoacidosis, etc.);
(2) Patients with severe primary diseases such as uncontrolled hypertension, myocardial infarction, coronary atherosclerosis, cerebral infarction, infectious liver disease, kidney failure, glomerulonephritis and so on;
(3) Patients who are suspicious or have been clearly diagnosed with skin problems, soft tissue injuries, osteoarthropathy, gastrointestinal diseases, blood diseases with bleeding tendencies, etc. that are not suitable for manual treatment;
(4) Pregnant and lactation patients;
(5) Those who have a serious gastrointestinal reaction after taking metformin and cannot continue to take the drug;
(6) Patients with mental illness, cognitive dysfunction, inability to cooperate with doctors;
(7) Easy to lose visit, such as frequent changes in the working environment;
(8) Patients who are participating in other clinical trials.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Waist circumference;
- Secondary Outcome Measures
Name Time Method Waist-Hip Ratio;TLR4mRNA;hs-CRP;Liver ultrasound;Visceral aliphatic factor;Blood sugar;Visceral fat;HOMA-IR;Index of ß-cell function in HOMA;IL-6;TLR4;Blood pressure;NF-?B p65;NF-?B p65mRNA;TNF-a;Blood lipid;Insulin;