The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.

Not Applicable

Completed

• Conditions: Liver and Muscle Glycogen Replenishment Post-exercise
• Interventions: Dietary Supplement: Sucrose; Dietary Supplement: Glucose

• Registration Number: NCT02344381
• Lead Sponsor: Northumbria University

Brief Summary

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for our ability to perform intense/prolonged endurance exercise. Therefore, it is important to replete these stores after an intense/prolonged endurance exercise session in order to recover and perform optimally during a subsequent exercise bout, especially if the next exercise session is within 24h (e.g. stage races such as the Tour de France, tournament-style competitions such as the Olympic games and ultra-endurance events).

Carbohydrate intake has been shown to increase the availability of glycogen in the muscle and liver after exercise. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. It has been observed that the ingestion of glucose will lead to a maximum rate of absorption of approximately \~1 g/min. However, if we also provide a different source of carbohydrate (fructose) then this is absorbed through a different pathway and therefore we can absorb up to \~1.75 g/min of carbohydrate. In addition, both carbohydrate sources are metabolised differently in the human body. By supplementing both glucose and fructose, we can potentially replenish the liver and muscle glycogen stores at a faster rate than ingestion of glucose only.

Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores post-exercise when supplemented in relatively high amounts. Therefore the aim of this study is to assess whether relative high amounts of sucrose ingestion will improve liver and muscle glycogen repletion after endurance exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Study First Submitted: 2015-01-16
• Study First Submitted QC: 2015-01-16
• Study First Posted: 2015-01-26
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-22
• Last Update Posted: 2015-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Healthy
• Endurance trained cyclists/triathletes
• VO2 max ≥ 50 ml/kg/min

Exclusion Criteria

• Use of medication
• Smoking
• Metabolic disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Glucose	Sucrose	Glucose ingestion post-exercise
Sucrose	Glucose	Sucrose ingestion post-exercise

Primary Outcome Measures

Name	Time	Method
change in liver glycogen concentration	5 h	The change in liver glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

Secondary Outcome Measures

Name	Time	Method
Change in muscle glycogen concentration	5 h	The change in muscle glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy
Plasma glucose concentration	5 h
Plasma insulin concentration	5 h
Plasma lactate concentration	5 h

Trial Locations

Locations (1)

Northumbria University; 🇬🇧 Newcastle upon Tyne, North East, United Kingdom