NL-OMON56544尚未招募不适用
Dynamic imaging of brain metabolism in ALS - Dynamic brain metabolism in ALS
niversitair Medisch Centrum Utrecht0 个研究点目标入组 123 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 123
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •a. ALS patients: definite, probable, probable-laboratory supported or possible
- •ALS according to the revised El Escorial criteria (Brooks 2000); only if ALS
- •patients have a family history of ALS, this will be defined as fALS.
- •b. Healthy control subjects without ALS: including family members of ALS
- •patients with or without an established mutation (i.e. we will not select them
- •based on any knowledge about a mutation they might carry), without any sign of
- •2. Age 18 - 80 years (inclusive)
- •3. Capable of thoroughly understanding the study information given; has signed
- •the informed consent.
- •4. Capable of climbing up the stairs, so the patient is able to climb up the
- •5. Willing and able to lie in an MRI scanner uninterrupted for 90 minutes.
排除标准
- •Tracheostomy, tracheostomal ventilation of any type, (non)-invasive
- •ventilation.
- •Any history or presence of brain injury, epilepsy, psychiatric illness and
- •other cerebral disease (not related to ALS).
- •Any intoxication or medication known to have an association with motor neuron
- •dysfunction, which might confound or obscure the diagnosis of motor neuron
- •Presence of pronounced swallowing disorders or orthopnoea (which make it
- •dangerous to lie supine in the MRI scanner and/or to drink 2H-glucose).
- •Diabetes mellitus
- •Contra-indications to MRI scanning according to hospitals 7T MRI screening
- •guideline of the UMC Utrecht.
- •Pregnancy
- •Any intoxication or medication that could influence the cerebral glucose
- •metabolism as judged by the researcher
研究者
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