In vivo imaging of brain metabolism in ALS - ALS brain metabolism

niversitair Medisch Centrum Utrecht0 个研究点目标入组 130 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•1. Subjects
•a. ALS patients: definite, probable, probable-laboratory supported or possible ALS according to the revised El Escorial criteria (Brooks 2000);
•- familar ALS is defined only if there is a family history of ALS.
•b. Healthy control subjects without ALS: including family members of ALS patients with and without an established mutation, without any sign of ALS.
•2. Age 18 - 80 years (inclusive)
•3. Capable of thoroughly understanding the study information given; has signed the informed consent.
•4. Capable of climbing up the stairs, so the patient is able to climb up the MRI table

•Tracheostomy, tracheostomal ventilation of any type, (non)-invasive ventilation.
•Any history or presence of brain injury, epilepsy, psychiatric illness and other cerebral disease (not related to ALS).
•Any intoxication or medication known to have an association with motor neuron dysfunction, which might confound or obscure the diagnosis of motor neuron disease.
•Presence of pronounced swallowing disorders or orthopnoea (which make it dangerous to lie supine in the MRI scanner).
•Contra-indications to MRI scanning according to hospitals 7T MRI screening guideline of the UMC Utrecht.
•Pregnancy

发起方

niversitair Medisch Centrum Utrecht