Bupropion Alone or Combined With Nicotine Gum
Phase 4
Completed
- Conditions
- Tobacco Dependence
- Interventions
- Registration Number
- NCT01621022
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 608
Inclusion Criteria
- Smoke 10 or more cigarettes per day
- Motivated to quit
- No physical or mental health issues that would prevent participation
- Not pregnant or willing to prevent pregnancy during treatment
Exclusion Criteria
- Carbon monoxide (CO) breath test score below 10 parts per million (ppm)
- Center for Epidemiologic Studies Depression Scale (CES-D) score greater than 16
- Heavy alcohol use
- History of eating disorder
- Suicidality
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Active bupropion-Active gum bupropion + nicotine gum 150 mg bupropion twice daily + 4 mg nicotine gum as needed (up to 12 pcs/day) Active bupropion-Placebo gum Active bupropion-Placebo gum 150mg bupropion twice daily + placebo gum as needed (up to 12 pcs/day) Placebo medication-Placebo gum Placebo bupropion-Placebo gum Placebo bupropion, twice daily, plus placebo gum as needed (up to 12 pcs/day)
- Primary Outcome Measures
Name Time Method 7-day point prevalence abstinence measured at 6 months 6 months No smoking, not evan a puff, during the 7 days prior to the 6 month follow-up
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UW Center for Tobacco Research and Intervention
🇺🇸Madison, Wisconsin, United States