Alkalized vs. non-alkalized cocoa: Effect on plasma appearance of flavanol stereoisomers, antioxidant status and on cardiometabolic parameters in healthy volunteers
Not Applicable
- Conditions
- Healthy subjectsprevention
- Registration Number
- DRKS00017550
- Lead Sponsor
- Institut Danone Ernährung für Gesundheit e.V.; Forschungsförderung 2009;
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Nonsmoker, written informed consent
Exclusion Criteria
Regular supplementation of vitamin C, vitamin E and phytochemicals (e.g., tea or red wine extract), cow’s milk allergy, lactose intolerance, diseases of the liver, the kidneys and the gastrointestinal tract, metabolic disorders (e.g., dyslipidemia, diabetes mellitus), eating disorders (anorexia nervosa, bulimia nervosa), pregnancy, lactation, drug abuse (narcotic and further psychotropic drugs), participation in another trial simultaneously or in the previous 30 days
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma appearance of (+)-catechin, (–)-catechin and epicatechin;<br>Plasma concentrations before and 0.5, 1.0, 1.5, 2.0, 3.0 and 6.0 h after consumption.
- Secondary Outcome Measures
Name Time Method Antioxidants (vitamin C, E, beta-carotene, uric acid), antioxidant capacity (TEAC), oxidative stress (peroxides, oxidized LDL, 8-hydroxy-2’deoxy-guanosin), insulin, lipids (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides), blood pressure;<br>Concentrations in serum/plasma before and 0.5, 1.0, 1.5, 2.0, 3.0 and 6.0 h after consumption.