NCT06081218招募中不适用
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
University Hospital, Lille2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年5月7日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Plasma endocannabinoids levels (pmol/ml)
研究概览
简要总结
The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cannabis consumer group:
- •Cannabis consumption > 100 times in lifetime, last exposure < 7 days, and recent exposure > 10 times in the month.
- •Positive toxicological urine test for ∆-9-THC.
- •Having a cannabis use disorder according to the CAST.
- •Healthy group:
- •Negative urine toxicological test for cannabis.
- •No regular cannabis use for more than 6 months once in a lifetime.
- •No cannabis consumption in the 6 months preceding the study.
排除标准
- •For all subjects :
- •Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
- •Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
- •Under medical treatment.
- •Presence of diagnosed neurological disorders.
- •Diagnosis of a psychotic picture entering axis I, DSM-
- •Chronic progressive disease or in remission.
- •Body mass index > 30 kg/m2 (i.e. presence of obesity).
研究组 & 干预措施
Chronic cannabis users
Experimental
干预措施: activity test (Other)
Healthy subjects
Sham Comparator
干预措施: activity test (Other)
结局指标
主要结局
Plasma endocannabinoids levels (pmol/ml)
时间窗: 2 weeks
次要结局
- regulating hormone of endocannabinoids (plasma levels of cortisol, ng/ml)(2 weeks)
- Blood marker of neurogenesis and neuroplasticity (plasma levels and BDNF, pg/ml)(2 weeks)
- change in cerebral muscular, oxygenation (HHB), (HbO2), (Hbtot) (arbitrary unit)(2 weeks)
- Cognitive function (selective attention, stroop test)(2 weeks)
- Oxygen consumption (VO2) (ml/min/kg)(2 weeks)
研究者
研究点 (2)
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