Study of Social Cognition by Morphological and Functional Imaging in Multiple Sclerosis Patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University Hospital, Bordeaux
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- Brain activation networks during MRI
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
In recent years, studies have brought knowledge of the difficulties of social cognition in Multiple Sclerosis (MS). The brain tissue alteration at the origin of these difficulties in social cognition mechanisms remain poorly understood. Although recent behavioral studies indicated social disturbances in many of these patients, functional studies investigating specific theory of mind in MS are lacking. The use of new techniques for morphological and functional Magnetic Resonance Imaging (MRI) can identify brain activation networks, mapping the achievement and tissue integrity may be related to disorders of social cognition and cognitive. The investigators propose to study social cognition in MS patients using morphological and functional imaging to determine the mechanisms underlying phenomena such as cerebral compensation and its relationship with cognitive impairment.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Brain activation networks during MRI
Time Frame: At inclusion (day 0)
To identify brain activation networks during the two paradigms of theory of mind and executive function in RRMS patients taking into account cognitive impairment.
Secondary Outcomes
- Reduction of volume of deep brain structures and reduction of cortical thickness(At inclusion (day 0))
- White matter skeleton on Fractional Anisotropy (FA) maps established by voxel-based.(At inclusion (day 0))