Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on the gain in knee extension strength in healthy volunteers.
Overview
Brief Summary
Local vibration is a non-invasive neuromuscular stimulation modality used in training and rehabilitation for its effects on neuromuscular function, particularly its ability to induce nervous adaptations. Its passive application is particularly useful in cases of motor deficit or immobilization.
Several studies, including our own, have shown that vibration protocols over several weeks can induce significant gains in muscle strength, particularly in the knee extensors. However, the parameters of application remain heterogeneous, particularly with regard to the duration of the interventions.
With this in mind, a prospective controlled study is being conducted in healthy subjects, comparing four modalities of local vibration intervention targeting the knee extensors: an intensive vibration protocol over 5 consecutive days (1 session of 30 or 60 minutes per day) and a protocol spread over 4 weeks at a rate of 3 weekly sessions of 30 or 60 minutes). The objective is to evaluate and compare their immediate and delayed effects on force production and corticospinal properties. The results of this study will thus help optimize recommendations regarding the use of local vibration in muscle strengthening and neuromuscular reconditioning strategies.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Men and women,
- •Aged between 18 and 45,
- •With a body mass index between 18 and 30 kg/m²,
- •Who have received detailed information about the study and have co-signed the consent form with the investigator,
- •Who are affiliated with or entitled to social security coverage.
Exclusion Criteria
- •Subjects with chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory conditions,
- •Personal history and/or risk factors for thrombosis,
- •Subjects undergoing antidepressant treatment,
- •Subjects who have taken corticosteroid treatment in the last 3 months,
- •Use of neuroactive substances likely to alter corticospinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) during the study period,
- •History of bone or ligament trauma to the lower limbs within the last 12 months,
- •Unable to perform the physical efforts required for the study,
- •Engaging in intense and unusual physical activity, including competitive sports, in the month preceding and during the protocol,
- •Presence of a skin lesion at the site where the vibrator is to be placed,
- •Simultaneous participation in another interventional medical trial,
Arms & Interventions
Group "5 days and 30 min"
Participants will follow a protocol involving local vibration applied to the quadriceps muscle for 5 consecutive days, at a rate of one 30-minute session per day.
Intervention: Local vibration protocol (Device)
Group "5 days and 60 min"
Participants will follow a protocol involving local vibration applied to the quadriceps muscle for 5 consecutive days, at a rate of one 60-minute session per day.
Intervention: Local vibration protocol (Device)
Group "4-weeks and 30 min"
Participants will follow a protocol involving local vibration applied to the quadriceps muscle over a period of 4 weeks, with 3 weekly sessions of 30 minutes each, for a total of 12 sessions.
Intervention: Local vibration protocol (Device)
Group "4-weeks and 60 min"
Participants will follow a protocol involving local vibration applied to the quadriceps muscle over a period of 4 weeks, with 3 weekly sessions of 60 minutes each, for a total of 12 sessions.
Intervention: Local vibration protocol (Device)
Outcomes
Primary Outcomes
Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on the gain in knee extension strength in healthy volunteers.
Time Frame: Five times: before the procedure (baseline); at the end of the procedure (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70), and 3 months (day 105 or day 126) after the procedure.
The primary endpoint will be the relative change in maximum isometric strength of the knee extensors (expressed as a percentage increased), assessed using an isokinetic dynamometer.
Secondary Outcomes
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on functional motor abilities and, more specifically, maximum voluntary strength(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on functional motor skills and, more specifically, jumping performance.(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on functional motor skills and, more specifically, the rate of force development (RFD)(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on corticospinal properties and, more specifically, on the level of voluntary activation(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on corticospinal properties and, more specifically, corticospinal excitability.(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on corticospinal properties and, more specifically, spinal excitability(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)
- Compare the effect of the duration of a local vibration program (5 days vs 4 weeks), as well as the effect of the duration of the sessions (30 min vs 60 min) on corticospinal properties and, more specifically, cortical activation of sensorimotor areas.(Five times: before the intervention (baseline); at the end of the intervention (day 21 or day 42 depending on the group); then 1 week (day 28 or day 49), 1 month (day 49 or day 70) and 3 months (day 105 or day 126) after the intervention.)