Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

Not Applicable

Recruiting

Interventions: Biological: Fasting blood test
Other: Subject interview
Other: Motor assessment
Other: Neurocognitive assessment
Other: Nutritional assessment
Other: Taste tests

Brief Summary: The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants:

* healthy volunteers

* patients with early Parkinson's disease

* patients with incipient Lewy body disease.

To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data.

This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Recruitment & Eligibility

Inclusion Criteria

Healthy volunteers:

Patients with idiopathic Parkinson's disease:

Patients with Lewy body disease:

Exclusion Criteria

Non-affiliated to national health insurance
Person under legal protection (curatorship, guardianship)
Person subject to a court order
Pregnant, parturient or breast-feeding women
Major unable to give consent
MMSE score < 15 and/or MoCA < 10
Known infection with COVID-19 in the 6 months prior to inclusion
Active smoker (> 4 cigarettes per day on a regular basis)
Subject with pacemaker (contraindication for bioelectrical impedancemetry)
Diabetic (type 1 or type 2)
Taking medication (in progress at the time of the study) that interferes with gustation

Arm && Interventions

Group	Intervention	Description
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Taste tests	-
Healthy volunteers	Fasting blood test	-
Healthy volunteers	Nutritional assessment	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Motor assessment	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Taste tests	-
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Nutritional assessment	-
Healthy volunteers	Subject interview	-
Healthy volunteers	Motor assessment	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Fasting blood test	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Nutritional assessment	-
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Neurocognitive assessment	-
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Subject interview	-
Healthy volunteers	Neurocognitive assessment	-
Healthy volunteers	Taste tests	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Subject interview	-
Patients with Idiopathic Parkinson's Disease (IPD) of course ≤ 3 years	Neurocognitive assessment	-
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Fasting blood test	-
Patients with Lewy body disease (LBD) progressing ≤ 3 years	Motor assessment	-

Primary Outcome Measures

Name	Time	Method
Average latency of taste-evoked potentials	After a 2-hour fasting period

Secondary Outcome Measures

Name	Time	Method

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