Patellofemoral Arthroplasty (PFA) Versus Total Knee Replacement (TKR) for Isolated Patellofemoral Osteoarthritis
Overview
- Phase
- N/A
- Intervention
- Knee arthroplasty
- Conditions
- Not specified
- Sponsor
- University of Aarhus
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Patient-reported outcomes (disease-specific and generic QoL instruments)
- Status
- Active, Not Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
This is a randomized comparison of PFA and TKR in treatment of isolated patellofemoral osteoarthritis.
Detailed Description
Isolated patellofemoral osteoarthritis can be a disabling condition of the knee necessitating knee arthroplasty. It is debated whether total knee replacement or isolated patellofemoral replacement is the better treatment option. This randomized trial attempts to give a qualified answer to the debate by comparing clinical outcome (range of movement, stability, effusion, patellofemoral tracking, tenderness, stair climbing), patient self assessment scores (EQ-5D, Oxford Knee Score, KOOS, SF-36, AKS), complications (infections, revisions), longevity (survival analysis) and cost (direct and indirect) for the two implant types. The Avon patellofemoral implant has been chosen, as this is the patellofemoral implant with the best documentation. The PFC Sigma CR total knee implant has been chosen as it a current standard implant and market leader.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Isolated PF-OA
Exclusion Criteria
- •Medial or lateral OA
Arms & Interventions
Avon patellofemoral replacement
Knee arthroplasty with insertion of patellofemoral joint replacement.
Intervention: Knee arthroplasty
PFC Sigma CR total knee replacement
Knee arthroplasty with total (tricompartmental) knee replacement.
Intervention: Knee arthroplasty
Outcomes
Primary Outcomes
Patient-reported outcomes (disease-specific and generic QoL instruments)
Time Frame: 10 years
The physical functioning score of the Short Form (36) Health Survey is the primary outcome measure of the study. Disease-specific patient-reported outcomes (Oxford Knee Score, KOOS and Kujala) and a second generic quality of life measure (EQ5D).
Secondary Outcomes
- Implant survival, clinician assessment and cost.(10 years)