MAINTAINING HEALTH IN OLD AGE THROUGH HOMEOSTASIS Phase II

Completed

• Conditions: healthy people; 10018424; reduced sensitivity to the actions of the hormone insulin

• Registration Number: NL-OMON41224
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

healthy volunteers from the general population

Exclusion Criteria

Fasting plasma glucose > 7 mmol/L

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Study the effect of intranasal application of insulin versus placebo on:<br /><br>1. Hypothalamic BOLD signals<br /><br>2. Using resting state functional magnetic resonance imaging (resting state<br /><br>fMRI)<br /><br>3. Blood trajectories of glucose and hormones</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Study the effect of intranasal application of insulin versus placebo on<br /><br>metabolomics and transcriptomics</p><br>