The Effects of Cannabidiol (CBD) Cream on Delayed Onset Muscle Soreness (DOMS and Performance After Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 4
- 主要终点
- Vertical Jump Test
研究概览
简要总结
Exercise-induced muscle damage (EIMD) results from unaccustomed exercise and can lead to delayed onset muscle soreness (DOMS). Impairments associated with EIMD and DOMS can result in moderate-to-severe discomfort and hindered performance. Recently, a compound derived from the cannabis plant, cannabidiol (CBD), has been used as a recovery tool for EIMD and DOMS. Despite the rising popularity of CBD products, their effectiveness in mitigating EIMD and DOMS is unknown. Specifically, to the investigators' knowledge, no clinical trials have been completed to assess the effects of topical CBD cream application on soreness, recovery and performance.
Therefore, the purpose of the present study was to investigate the effects of CBD cream on DOMS and performance after an intensive lower-body exercise protocol. Specifically, the study's aims were:
Aim 1: To assess the effect of topical CBD cream administration on muscle soreness following fatiguing exercise.
Hypothesis 1: CBD cream would decrease perceived muscle soreness when compared to a placebo or control (no cream) group.
Aim 2: To assess the effect of topical CBD cream administration on muscular performance following fatiguing exercise.
Hypothesis 2: Recovery of muscular power would be quicker when CBD cream is applied, compared to a placebo or control (no cream) group.
Aim 3: To assess if topical CBD cream has a localized (if any) or systemic effect on muscle soreness.
Hypothesis 3: Improvements in muscle soreness would only be observed in localized muscles around where the CBD cream was applied.
详细描述
This study is a randomized, double-blind, placebo-controlled experiment examining if CBD cream impacts recovery after exercise. It will be investigated whether or not the potential effects of CBD cream are localized or systemic within the lower body muscles (quadriceps and hamstrings). Furthermore, the study will examine if these potential effects on recovery impact the expected decrements on lower body performance in the days following an intense exercise bout. Overall, the main objective is to determine whether or not CBD cream is an effective recovery method for those who are experiencing DOMS.
Participants will be recruited from volunteers who reside in the Lexington area. Those who participate within the study will be randomly placed into one of three groups by the PI, Dr. Stuart Best: a group that will apply the CBD cream (Group 1), a group that will apply the placebo moisturizer cream (Group 2), or a control group that does not participate in any cream-related procedures (Group 3).
The research participants and research personnel conducting the testing will be blinded to who is in the CBD and placebo groups throughout the study. Furthermore, the PI, who will not participate in any form of testing, will also be responsible for the storage and distribution of the CBD and placebo creams during the study. Those in Group 3 (the control group) will be aware that they are in the control group, as they will be skipping the steps involving cream application. The protocols for Group 1 and Group 2 will be identical and the respective cream will be made available to the testers and participants in identical containers.
A summary of the participant groups is shown below:
Group 1 - CBD Group; This group will apply the CBD cream in accordance with the manufacturer's recommendations throughout the study. Application procedures are described in a section below.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
The research participant's and research personnel conducting the testing will be blinded to who is in the CBD and placebo groups throughout the study. Those in Group 3 (the control group) will be aware that they are in the control group, as they will be skipping the steps involving cream application. The protocols for Group 1 and Group 2 will be identical and the respective cream will be made available to the testers and participants in identical containers.
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physically healthy
- •Age 18-45
- •Available for 5 sessions over the span of 2 weeks
- •Untrained (have not been participating in a structured resistance training routine for the past 2 months that includes 2 days of lower body resistance training per week)
排除标准
- •Have not suffered a lower body injury in the previous 3 months
- •Be allergic to any ingredients within the CBD or placebo creams (ingredients listed in informed consent form)
- •Be pregnant
结局指标
主要结局
Vertical Jump Test
时间窗: Baseline and immediately post exercise, then 24, 48, and 72 hours post-exercise (pre- and post-cream/rest).
The vertical jump, or countermovement jump (CMJ), test will utilize the ForceDecks Dual Force Plate System by Vald Performance to measure peak force production and vertical jump height (one plate for each leg; sampling frequency = 1,000 Hz).
次要结局
- Pressure-Pain Threshold Test(Baseline and immediately post exercise, then 24, 48, and 72 hours post-exercise (pre- and post-cream/rest).)
- Peak Isokinetic Torque Test(Baseline and Session 5 (72 hours post-exercise))
研究者
Joseph Pastina
Investigator
University of Kentucky