Effects of two different isoflavone supplement preparations on gene-expression in postmenopausal wome
Completed
- Conditions
- geen specifieke aandoening door het gebruik van microarraysnvt
- Registration Number
- NL-OMON35572
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 72
Inclusion Criteria
women
50-70 year
postmenopausal
Exclusion Criteria
- current use of contraceptives containing hormones
- current use of hormone replacement therapy
- regular soy product use (more than once a week)
- regular isoflavone supplement use (more than once a week)
- current use of medication containing sexhormones or sexhormone-triggering compounds
- current use of anti-inflammatory medicines
- use of antibiotics in the past 3 months
- severe heart disease
- diabetes
- thyroid disorders --> use of medicines for thyroid disorders
- removed thyroid gland
- complete ovarectomy
- prior diagnosis of cancer in medical history
- alcohol and drug abuse
- current smoker
- BMI >35 kg/m2
- allergy to soy (products)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is gene-expresion in PBMCs measured by micro-arrays </p><br>
- Secondary Outcome Measures
Name Time Method <p>Isoflavone levels in plasma<br /><br>Gene - expression measured by micro-arrays in adipose tissue<br /><br>Isoflavone levels in adipose tissue.</p><br>