Evaluation of the effect of adding duloxetine to exercise therapy on pain and function of patients with knee osteoarthritis

Mazandaran University of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2023年10月16日

适应症

试验速览

暂无简介。

•Patients aged 40-80 years
•Knee pain more than 14 days per month and the average pain score Visual Analogue score (VAS) = 4 during the 3-month period before the first visit
•The grade of knee osteoarthritis is 2 and 3 based on the Kallgren-Lawrence classification
•The knee should be stable
•Good cognitive status
•The ability to understand the study protocol and the mental ability to answer the questions of the questionnaires
•Willingness to participate in the study

•Deformity of the knee
•Spondylolisthesis
•Lumbar radiculopathy
•Inflammatory arthritis
•Autoimmune disorder
•Septic arthritis
•Any other concomitant disease such as liver and kidney disease
•Contraindications for duloxetine (current use of monoamine oxidase inhibitors or poorly controlled angle-closure glaucoma)
•Previous exposure to duloxetine
•Concomitant use of other drugs that affect the central nervous system (such as benzodiazepines)
•History of allergy to duloxetine
•Metabolic diseases
•Anticoagulation therapy
•History of aggressive knee treatments in the last 6 months
•Knee joint replacement at any time
•Current infection in the affected limb

发起方