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Clinical Trials/IRCT20230821059204N1
IRCT20230821059204N1
Not yet recruiting
Phase 3

Evaluation of the effect of adding duloxetine to exercise therapy on pain and function of patients with knee osteoarthritis

Mazandaran University of Medical Sciences0 sites60 target enrollmentTBD
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ConditionsOsteoarthritis of knee.Osteoarthritis of knee

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Osteoarthritis of knee.
Sponsor
Mazandaran University of Medical Sciences
Enrollment
60
Status
Not yet recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Interventional
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Patients aged 40\-80 years
  • •Knee pain more than 14 days per month and the average pain score Visual Analogue score (VAS) \= 4 during the 3\-month period before the first visit
  • •The grade of knee osteoarthritis is 2 and 3 based on the Kallgren\-Lawrence classification
  • •The knee should be stable
  • •Good cognitive status
  • •The ability to understand the study protocol and the mental ability to answer the questions of the questionnaires
  • •Willingness to participate in the study

Exclusion Criteria

  • •Deformity of the knee
  • •Spondylolisthesis
  • •Lumbar radiculopathy
  • •Inflammatory arthritis
  • •Autoimmune disorder
  • •Septic arthritis
  • •Any other concomitant disease such as liver and kidney disease
  • •Contraindications for duloxetine (current use of monoamine oxidase inhibitors or poorly controlled angle\-closure glaucoma)
  • •Previous exposure to duloxetine
  • •Concomitant use of other drugs that affect the central nervous system (such as benzodiazepines)

Outcomes

Primary Outcomes

Not specified

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