Study comparing the ability of two medications, namely oral tablets of mycophenolate mofetil and cyclophosphamide, in keeping disease well controlled in patients with frequently relapsing or steroid dependent nephrotic syndrome
- Conditions
- Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
- Registration Number
- CTRI/2022/10/046891
- Lead Sponsor
- AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients with idiopathic steroid sensitive nephrotic syndrome with frequent relapses or steroid dependence in the preceding 12-months and with parents willing to give informed written consent and child giving informed written assent
Known secondary etiology (e.g., lupus erythematosus, IgA nephropathy, amyloidosis)
Initial or late steroid resistance, currently or historically
Therapy with oral or intravenous cyclophosphamide or MMF ever in the past
Therapy with cyclosporine, tacrolimus, azathioprine or rituximab in the past 6 months
Inability to swallow tablets or capsules of MMF
Impaired renal function, as indicated by eGFR <60 mL/min per 1.73 m²
Leukopenia, neutropenia, thrombocytopenia, elevated transaminases
Known chronic infection (tuberculosis, HIV, hepatitis B or C) or malignancy
Residing more than 100 km away or unwilling to come for regular follow-up
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method