Gender and Opioid Consumption
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- postoperative morphine consumption
研究概览
简要总结
Opioids are widely used for pain relief after major abdominal surgeries[1]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference on response to opioid analgesics after abdominal surgeries will be assessed regarding; analgesic duration (primary variable), frequency of analgesic requirement, total opioid consumption, Opioid related complications (respiratory depression, Nausea & vomiting, itching, over-sedation, delayed intestinal motility).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I and II Cases scheduled for elective intraabdominal surgeries
排除标准
- •diabetes,
- •postmenopausal females,
- •laparoscopic surgery,
- •regional anesthesia emergency procedures,
- •hepatectomy,
- •Renal impairment, and
- •hepatic impairment,
- •mental and psychiatric disorders.
研究组 & 干预措施
Male group
All male patients scheduled for upper abdominal surgeries
干预措施: postoperative morphine (Drug)
Female group
All female patients scheduled for upper abdominal surgeries
干预措施: postoperative morphine (Drug)
结局指标
主要结局
postoperative morphine consumption
时间窗: 24 hours after surgery
次要结局
未报告次要终点