Platelet Sub-study of the Neomindset Trial
- Conditions
- Acute Coronary Syndrome
- Registration Number
- NCT05767723
- Lead Sponsor
- Hospital Israelita Albert Einstein
- Brief Summary
The general purpose of the Neomindset trial is to evaluate the non-inferiority hypothesis for ischemic events and the superiority hypothesis for bleeding events resulting from platelet P2Y12 receptor inhibitors given as monotherapy in comparison with conventional dual antiplatelet therapy in acute coronary syndrome patients treated with percutaneous coronary intervention.
The platelet sub-study will be conducted at the Hospital Israelita Albert Einstein. This sub-study will recruit randomized patients from the Neomindset trial to evaluate platelet function after at least 30 days of study treatment with either P2Y12 inhibitor monotherapy or dual antiplatelet therapy.
- Detailed Description
The platelet sub-study will be conducted at the Hospital Israelita Albert Einstein. This sub-study will recruit randomized patients from the Neomindset trial to evaluate platelet function after at least 30 days of study treatment with either P2Y12 inhibitor monotherapy or dual antiplatelet therapy.
These patients will undergo blood sampling and measurement of platelet function after being treated with P2Y12 inhibitor monotherapy or dual antiplatelet therapy for at least 30 days.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 48
Not provided
- Acute coronary syndrome on index admission treated in a conservative way or by unsuccessful percutaneous intervention or surgically;
- Presence of residual lesions which are likely to require future treatment in the next 12 months;
- Fibrinolytic therapy < 24 hour before randomization;
- Need of oral anticoagulation with warfarin or new anticoagulants;
- Chronic bleeding diathesis;
- Active or recent major bleeding (in-hospital);
- Prior intracranial hemorrhage;
- Ischemic cerebrovascular accident < 30 days;
- Presence of brain arteriovenous malformation;
- Index event of non-atherothrombotic etiology (i.e., stent thrombosis, coronary embolism, spontaneous coronary artery dissection, myocardial ischemia due to supply/demand imbalance);
- Potential or scheduled cardiac or non-cardiac surgery in the next 12 months;
- Platelet count < 100,000 cells/mm3 or > 700,000 cells/mm3;
- Total white blood count < 3,000 cells/mm3;
- Suspected or documented active liver disease (including laboratory evidence of hepatitis B or C);
- Receiver of heart transplant;
- Known allergies or intolerance of acetylsalicylic acid, clopidogrel, ticlopidine, ticagrelor, prasugrel, heparin or antiproliferative agents from the limus-family of drugs;
- Subject with life expectation lower than 1 year;
- Any significant medical condition that, in the investigator's opinion, could interfere with the ideal participation of the subject in the study;
- Participation in other study in the past 12 months, unless a direct benefit to the subject can be expected.
- Impossibility of being treated with dual antiplatelet therapy for 12 months, based on investigator judgement.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Platelet function using PFA-100 30 days of treatment Platelet function using PFA-100
- Secondary Outcome Measures
Name Time Method Platelet function using CHRONO-LOG 30 days of treatment Platelet function using CHRONO-LOG
Platelet function using Rotem-platelet 30 days of treatment Platelet function using Rotem-platelet
Coagulation test using thromboelastogram 30 days of treatment Coagulation test using thromboelastogram
Trial Locations
- Locations (1)
Hospital Israelita Albert Einstein
🇧🇷São Paulo, Brazil
Hospital Israelita Albert Einstein🇧🇷São Paulo, Brazil