Role of innate immunity and fibrinolysis in the development of post thrombotic syndrome: a case-control study
Recruiting
- Conditions
- post phlebitic syndrome1006447710014523
- Registration Number
- NL-OMON35458
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
All adult and consenting.;Cases:
- Having had a DVT 2-10 years ago
- PTS according to the Villalta scale: Villalta score >=5 on two or more consecutive visits that were at least 3 months apart or venous ulceration;Controls:
- Having had a DVT 2-10 years ago
- No PTS;Healthy controls:
- Never had a DVT during their life
- No venous insufficiency caused by other factors (CEAP<3)
Exclusion Criteria
- Preexistent venous insufficiency (skin signs C3-C6 on CEAP score or requiring ECS therapy)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome will be the difference in levels of plasma concentrations<br /><br>of markers in relation to the outcome PTS between participants with PTS and<br /><br>participants without PTS</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Dose-dependent relation between the level of markers and severity of PTS.<br /><br>- Plasma concentration of markers in healthy controls that never had a DVT,<br /><br>compared to patients that have had a DVT.</p><br>