Determination of calprotectin (S100A8/A9 protein) in serum and feces vulgaris and endoscopic evaluation of intestinal and colon mucosa from psoriasis patients - Topoproteomanalyse of skin and intestinal biopsies
- Conditions
- L40.0K50.0Psoriasis vulgarisCrohn disease of small intestine
- Registration Number
- DRKS00003445
- Lead Sponsor
- niversitätsklikum MagdeburgKlinik für Dermatologie und Venerologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
10 asymptomatic subjects in cancer prevention
- 40 patients with psoriasis without gastrointestinal symptoms
Aged between 18 and 75 years.
- Written inform consent
Exclusion Criteria
Gastrointestinal malignant tumors at medical history and current
- Diseases that make endoscopic examinations impossible
- Patients with psoriasis vulgaris in the 4 weeks prior inclusion into the study treated with systemic methotrexate, cyclosporine, retinoids, Glucocorticoids or biologics
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determining the prevalence of increased fecal and systemic calprotectin levels in patients with psoriasis vulgaris
- Secondary Outcome Measures
Name Time Method Endoscopic and histological evaluation of the ileum and colon of patients with psoriasis vulgaris by ileo-colonoscopy<br> - capsule-endoscopic examination of the small intestine of patients with psoriasis vulgaris for the presence of Crohn's disease of the duodenum, jejunum or ileum<br> - Correlation of the measured systemic cutaneous and fecal Calprotectin values with the disease activity of psoriasis vulgaris and with the endoscopic and histological activity levels of IBD<br> - Topoproteom analysis of tissue samples from skin and intestine in patients with psoriasis vulgaris regarding Th17-mediated inflammatory processes<br> - Evaluating the impact of a disease-specific therapy on the progression of psoriasis in patients with evidence of IBD