International Registry for Severe Chronic Neutropenia
- Conditions
- Neutropenia
- Registration Number
- NCT00004342
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Brief Summary
OBJECTIVES: I. Document the clinical course of severe chronic neutropenia (SCN).
II. Monitor and assess long term safety of primary treatment in SCN patients in the United States, Canada, Europe, and Australia.
III. Study the incidence and outcome of adverse events such as osteoporosis, splenomegaly, cytogenetic abnormalities, myelodysplastic syndrome, and leukemia.
IV. Evaluate growth and development and hematologic parameters. V. Monitor for clinically significant changes in primary treatment response over time.
VI. Establish a physician network to increase the understanding of SCN. VII. Establish a demographic database to allow for future research.
- Detailed Description
PROTOCOL OUTLINE:
Patients are treated by the referring physician as medically indicated. Clinical data are collected at baseline and then every 6 months.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (10)
Dana-Farber/Boston Children¹s Cancer and Blood Disorders Center
🇺🇸Boston, Massachusetts, United States
Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
Leeds Teaching Hospitals, Yorkshire Regional Centre for Paediatric Oncology & Haematology
🇬🇧Leeds, England, United Kingdom
University of Massachusetts
🇺🇸Worcester, Massachusetts, United States
Monash University
🇦🇺Melbourne, Victoria, Australia
St. Joseph's Children's Hospital
🇺🇸Paterson, New Jersey, United States
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
University of Washington School of Medicine
🇺🇸Seattle, Washington, United States
CancerCare Manitoba
🇨🇦Winnipeg, Manitoba, Canada