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EMD SERONO RESEARCH & DEVELOPMENT INSTITUTE, INC.

🇺🇸United States
Ownership
Subsidiary
Employees
-
Market Cap
-
Website

Phase 1 Study of M9466 Combined With Carboplatin and Platinum-based Anticancer Therapy (DDRiver 521)

Phase 1
Withdrawn
Conditions
Advanced Solid Tumors
Interventions
First Posted Date
2024-12-06
Last Posted Date
2025-06-17
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
54
Registration Number
NCT06719973
Locations
🇯🇵

National Cancer Center Hospital - Dept of Respiratory Medicine, Chuo-ku, Japan

Phase 1b/2 Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced NSCLC (Substudy NSCLC)

Phase 1/2
Not yet recruiting
Conditions
Non-Small Cell Lung Cancer
Interventions
First Posted Date
2025-05-05
Last Posted Date
2025-05-12
Lead Sponsor
Merck Healthcare KGaA
Target Recruit Count
51
Registration Number
2024-517818-15-00
Locations
🇦🇹

Medical University Of Vienna, Vienna, Austria

🇦🇹

Ordensklinikum Linz GmbH, Linz, Austria

🇫🇷

Hopital Saint Antoine, Paris Cedex 12, France

and more 35 locations

Anti-GD2 ADC M3554 in Advanced Solid Tumors

Phase 1
Recruiting
Conditions
Advanced Solid Tumor
Interventions
First Posted Date
2024-10-15
Last Posted Date
2025-06-15
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
52
Registration Number
NCT06641908
Locations
🇺🇸

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York - Memorial Sloan Kettering Cancer Center (CC)- Westc, New York, New York, United States

🇺🇸

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

and more 6 locations

M9466 in Combination with Topoisomerase 1 Inhibitors-based Regimens in Advanced Solid Tumors and Colorectal Cancer (DDRiver 511)

Phase 1
Suspended
Conditions
Advanced solid tumors and colorectal cancer
Interventions
First Posted Date
2024-10-21
Last Posted Date
2024-10-21
Lead Sponsor
Merck Healthcare KGaA
Target Recruit Count
13
Registration Number
2024-514155-15-00
Locations
🇪🇸

Hospital Quironsalud Barcelona, Barcelona, Spain

🇪🇸

Hospital Universitario Quironsalud Madrid, Pozuelo De Alarcon, Spain

Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

Phase 2
Recruiting
Conditions
Ovarian Cancer
Interventions
Drug: Tuvusertib (M1774)
Drug: Lartesertib (M4076)
First Posted Date
2024-05-29
Last Posted Date
2025-02-03
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
60
Registration Number
NCT06433219
Locations
🇺🇸

Memorial Sloan Kettering Cancer Center, New York, New York, United States

🇺🇸

Icahn School of Medicine at Mount Sinai PRIME - Mount Sinai - PRIME, New York, New York, United States

🇦🇺

Liverpool Hospital - PARENT, Liverpool, Australia

and more 55 locations

Study of Avelumab and Tuvusertib in Participants With Advanced Urothelial Cancer That Has Progressed on Prior Anti-PD-(L)1 Therapy (JAVELIN DDRiver Bladder)

Phase 2
Not yet recruiting
Conditions
Urothelial Carcinoma
Interventions
First Posted Date
2024-05-22
Last Posted Date
2024-07-31
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
70
Registration Number
NCT06424717
Locations
🇺🇸

Please Contact U.S. Medical Information, Rockland, Massachusetts, United States

🇩🇪

Please Contact the Communication Center, Darmstadt, Germany

M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)

Phase 1
Recruiting
Conditions
Advanced Solid Tumor
Interventions
First Posted Date
2024-05-20
Last Posted Date
2025-06-15
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
96
Registration Number
NCT06421935
Locations
🇦🇺

GenesisCare North Shore (Oncology), St Leonards, Australia

🇺🇸

NEXT Oncology - PARENT, New York, New York, United States

🇺🇸

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

and more 16 locations

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)

Phase 1
Active, not recruiting
Conditions
Head and Neck Cancer
Interventions
Radiation: intensity-modulated radiation therapy (IMRT)
First Posted Date
2023-09-28
Last Posted Date
2024-07-18
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
18
Registration Number
NCT06056310
Locations
🇺🇸

Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida, United States

🇺🇸

Karmanos Cancer Institute - PARENT, Detroit, Michigan, United States

🇺🇸

Montefiore Medical Center PRIME, Bronx, New York, United States

and more 20 locations

Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322)

Phase 1
Active, not recruiting
Conditions
Non-Small Cell Lung Cancer
Interventions
First Posted Date
2023-05-31
Last Posted Date
2025-01-27
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
180
Registration Number
NCT05882734
Locations
🇺🇸

UCLA Hematology and Oncology - Santa Monica, Santa Monica, California, United States

🇺🇸

UPMC Cancer Center, Pittsburgh, Pennsylvania, United States

🇺🇸

Tennessee Cancer Specialists - Biomedical Research, Knoxville, Tennessee, United States

and more 51 locations

Study of M5049 in DM and PM Participants (NEPTUNIA)

Phase 2
Active, not recruiting
Conditions
Polymyositis
Dermatomyositis
Interventions
Drug: Placebo
Drug: M5049 high dose
First Posted Date
2022-12-14
Last Posted Date
2025-06-17
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
40
Registration Number
NCT05650567
Locations
🇺🇸

Neuromuscular Research Center, Phoenix, Arizona, United States

🇺🇸

HonorHealth Research Institute - Bob Bove Neuroscience Institute-Neuroscience Research, Scottsdale, Arizona, United States

🇺🇸

Mayo Clinic Scottsdale (6365), Scottsdale, Arizona, United States

and more 28 locations
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