The AIM-to-OBserve study: Adipokines and Inflammatory Markers in childhood OBesity

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 140

Inclusion Criteria

Patientgroup:
6-16 years of age
BMI (>30 kg/m2 projected at the age of18 years), according to international standards, see also Hirasing RA, Fredriks AM, van BS, Verloove-Vanhorick SP, Wit JM. [Increased prevalence of overweight and obesity in Dutch children, and the detection of overweight and obesity using international criteria and new reference diagrams]. Ned Tijdschr Geneeskd 2001 July 7;145(27):1303-8.;Controls:
Sex and age matched to patient group
-0.5 SD Newly referred patients to the pediatric outpatient department, by general practitioners, for the reason of:
- Suspected allergy or asthma
- Analysis of complaints of fatigue/malaise
- Prediction of final height
- Habitual constipation (i.e. constipation not explained by a disease)

Exclusion Criteria

Patientgroup:
- Intoxication (smoking, i.e. sigaret use, drug-use)
- Acute illness (fever)
- Mental retardation
- Allergy with positive RAST for food/inhalation allergy and (history of) Muller class I-II reaction (i.e. severe systemic allergy/anaphylaxis)
- Asthma (based on doctors* diagnosis: history of recurrent wheezing, obstructive
lung function tests with reversibility after administration of β2-sympathicomimetics,
use of asthma-medication)

Controls:
- Intoxication (smoking, drug-use)
- Acute illness (fever)
- Mental retardation
Exclusion criteria for involved referrals:
- Allergy with positive RAST for food/inhalation allergy and (history of) Muller class I-II reaction (i.e. severe systemic allergy/anaphylaxis)
- Asthma (based on doctors* diagnosis: history of recurrent wheezing, obstructive lung function tests with reversibility after administration of β2-sympathicomimetics, use of asthma-medication)
- Complaints of fatigue/malaise explained by M.Pfeiffer, inflammatory or infectious illness (e.g. inflammatory bowel disease, (viral) hepatitis, rheumatologic disease)
- Assessment of height when short or tall stature (height ± 1 SD of target height (TH), so height outside TH-range) or endocrine explanation for abnormal growth pattern (e.g. growth hormone deficiency)

The exclusion-criteria are formulated on the assumption that these might influence adipokine/inflammatory profiles.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) the difference in adipokine/inflammatory profiles between obese children and<br /><br>normal weight controls. 2) the relation between adipokine/inflammatory profiles<br /><br>and clinical parameters for obesity. </p><br>

Secondary Outcome Measures