Are the blood plasma adipokine and inflammatory marker concentrations different between obese and non-obese type 2 diabetes patients?

Completed

• Conditions: Type 2 diabetes; Nutritional, Metabolic, Endocrine; Non-insulin-dependent diabetes mellitus

• Registration Number: ISRCTN97519965
• Lead Sponsor: niversity Maastricht (UM) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07-24
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

A total of 60 Caucasian males (aged between 40 and 75 years) are selected to participate in this study: 20 non-obese (body mass index [BMI] less than 30 kg/m^2) and 20 obese (BMI greater than 35 kg/m^2) type 2 diabetes patients, and 20 healthy, non-obese subjects (BMI less than 30 kg/m^2). Type 2 diabetes patients are diagnosed for at least 12 months prior to investigation and are all treated with oral blood glucose lowering medication. All subjects are sedentary and do not participate in any regular exercise program and/or caloric intake restriction intervention for at least 5 years.

Exclusion Criteria

1. Type 1 diabetes patients
2. Females
3. Non-adult patients
4. Deregulated diabetes

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fasting blood samples are collected to compare the following between groups:<br>1. Adiponectin<br>2. Resistin<br>3. Leptin<br>4. Interleukin-6<br>5. High-sensitivity C-reactive protein<br>6. Tumour necrosis factor alpha<br>7. Free fatty acid concentrations<br><br>Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.

Secondary Outcome Measures

Name	Time	Method
Fasting blood samples are collected to compare the following between groups:<br>1. Glycosylated haemoglobin (HbA1c) content<br>2. Blood lipid profile<br>3. Insulin level<br>4. Homeostatic Model Assessment (HOMA) index<br>5. Fat-free mass<br>6. Whole-body oxygen uptake<br>7. Workload capacity<br><br>Subjects arrived at the hospital by car or public transportation and reported at the laboratory at 08.00 AM after an overnight fast. After 20 minutes of rest a venous blood sample was collected.