Macrophage infiltration and adipocytokine expression in subcutaneous and visceral fat tissue in patients with Cushing's syndrome.

Completed

• Conditions: Cushing's syndrome; hypercortisolism; 10021112; 10000546; 10047066

• Registration Number: NL-OMON37047
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- patients with active Cushing's syndrome during adrenalectomy, confirmed by increased 24h urine cortisol excretions and a positive dexamethasone supression test.
- over 18 years old.
- informed consent

Exclusion Criteria

none

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- a) amount of macrophage infiltration in fat tissue<br /><br>- b) mRNA expression of adipokines<br /><br>- c) mRNA expression of proinflammatory cytokines<br /><br>cytokines and adipokines that can be measured in blood of patients suffering<br /><br>from Cushing's syndrome and controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>