Alveolar Macrophage ImmuNOmetabolism study
Recruiting
- Conditions
- Pneumonia, pulmonary diseases
- Registration Number
- NL-OMON29138
- Lead Sponsor
- AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
• 18-60 years of age
• non-smoking, or ex-smoking (=2 years ago)
• no respiratory diagnosis of asthma or COPD
• no history of bronchiectasis, lung cancer, pneumothorax or other significant respiratory disease.
• no history of bleeding disorder
• not using anti-inflammatory and/or anticoagulant medication
• no major comorbidities
• BMI 17-30 kg.m2
Exclusion Criteria
Individuals who are deemed immunocompromised due to disease or medication
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To analyse immunometabolic pathways in AMs of healthy volunteers after ex vivo” exposure to respiratory pathogens or components thereof using an integrative approach.
- Secondary Outcome Measures
Name Time Method 1. To obtain exploratory data on the composition and diversity of the lung microbiome.<br>2. To utilize Optical Coherence Tomography (OCT) and Confocal Laser Endomicroscopy (CLE) to visualize in vivo the healthy alveolar compartment and airway wall layers and compare this to airway wall histology.