Effect of magnesium supplementation in treatment of gestational diabetes

Phase 2

Conditions: Gestational diabetes mellitus.
Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium
O24.9

Registration Number: IRCT20170513033941N25

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 40

Inclusion Criteria

Patients with gestational diabetes mellitus.
Individuals aged 18 to 40 years.

Exclusion Criteria

Taking magnesium and antioxidants supplements 3 months before the intervention
Needing insulin therapy
Pre-eclampsia
Eclampsia
Hypo and hyperthyroidism
Smokers

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expressed levels of TNF-a gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of IL-1 gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of IL-8 gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.

Secondary Outcome Measures

Name	Time	Method
Expressed levels of TGF-B gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Expressed levels of VEGF gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;Newborn's head circumference. Timepoint: Delivery time. Method of measurement: Tape.;Newborn's weight. Timepoint: Delivery time. Method of measurement: Scale.;Polyhydramnios. Timepoint: End-of-trial. Method of measurement: Sonography.;Newborn length. Timepoint: The first 24 h after birth. Method of measurement: Girth measuring tape.