Effect of supplementation in treatment of women with polycystic ovary syndrome
Phase 3
- Conditions
- Polycystic ovarian syndrome.Polycystic ovarian syndromeE28.2
- Registration Number
- IRCT201706075623N121
- Lead Sponsor
- Vice chancellor for research, Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
Aged 18–40 years old
Patients with PCOS according to Rotterdam criteria
Exclusion Criteria
Pregnant during the intervention
Metabolic disorders, including androgen-secreting tumors, thyroid dysfunction, diabetes
insulin injection
Taking anti-inflammatory drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hs-CRP. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Elisa kit.;Expressed levels of IL-1 gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Expressed levels of IL-8 gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Expressed levels of TNF-a gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.
- Secondary Outcome Measures
Name Time Method Total antioxidant. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Nitric oxide. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Expressed levels of TGF-ß gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Expressed levels of VEGF gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: PCR.;Malondialdehyde. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.;Protein carbonyl. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Spectrophotometry.