Effect of combined magnesium and vitamin E supplementation in treatment of diabetic foot ulcer

Phase 2

• Conditions: Diabetic foot ulcer.; Non-insulin-dependent diabetes mellitus and with peripheral circulatory complications; E14.5

• Registration Number: IRCT2017090533941N21
• Lead Sponsor: Kashan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 5 November 2019

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with grade 3 diabetic foot ulcer
Aged 40 to 85

Exclusion Criteria

Pregnant and breastfed patients
Participants who consumed magnesium, vitamin E or other antioxidative supplements during past 3 months
Taking anti-inflammatory agents
Change in consuming medications throughout the study
Patients with history of diseases which influence the development of diabetic foot ulcer including chronic trauma

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Elisa kit.;Insulin resistance. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Calculation using HOMA formula.;Healing of diabetic foot ulcer. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Decrease of the wound size relative to original size: ulcer length (cm), ulcer width (cm), Ulcer depth (cm).