Pain relief after Gall bladder surgery with help of nerve block.
Phase 2/3
Not yet recruiting
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2023/01/048983
- Lead Sponsor
- Dr Raghavendra Ullas L
- Brief Summary
TAP block has been used as a Postoperative analgesia technique for Laparoscopic surgery whereTAP block is given before the emergence from anesthesia which have proven to reducepostoperative opioid consumption and has helped in early mobilisation and reduce risk ofcomplications.
we intend to study that of addition of dexamethasone to ropivacaine in USG-TAP block enhances the duration of post operative analgesia significantly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- 1.ASA I to II patients.
- 2.Aged between 20 to 50 years.
- 3.Normal liver and renal function test, Coagulation profile.
- 4.Undergoing laparoscopic cholecystectomy under General anaesthesia.
Exclusion Criteria
- 1.Patients with history of allergy to local Anaesthetics.
- 2.Patients with history of mental disorders.
- 3.Patient Refusal.
- 4.Morbid obesity (BMI>40), Coagulopathy and significant cardiovascular respiratory, renal, hepatic or metabolic diseases or CNS disorders.
- 5.Infection at site of procedure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the duration of Post operative analgesia using Ropivacaine (0.5%) alone and Ropivacaine with Dexamethasone in bilateral transversus abdominis plane block after general anesthesia for laparoscopic cholecystectomy. To Note VAS score at 0,1,2,4,8,12,16,18,24 hours
- Secondary Outcome Measures
Name Time Method To compare Hemodynamic parameters and assess Post operative Visual analogue scale Pain score. To Note VAS score at 0,1,2,4,8,12,16,18,24 hours
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain dexamethasone's analgesic synergy with ropivacaine in USG-TAP blocks for laparoscopic cholecystectomy?
How does the ropivacaine-dexamethasone combination in USG-TAP blocks compare to standard opioid-based analgesia in postoperative pain management effectiveness?
Are there specific biomarkers that can predict enhanced analgesic response duration when dexamethasone is added to ropivacaine in TAP blocks for abdominal surgeries?
What are the potential adverse events associated with dexamethasone-ropivacaine mixtures in ultrasound-guided regional anesthesia for laparoscopic procedures?
What alternative adjuvants or drug combinations are being explored to enhance the duration of postoperative analgesia in transversus abdominis plane blocks compared to dexamethasone?
Trial Locations
- Locations (1)
Rajarajeswari Medical college and Hospital
🇮🇳Bangalore, KARNATAKA, India
Rajarajeswari Medical college and Hospital🇮🇳Bangalore, KARNATAKA, IndiaDr Raghavendra Ullas LPrincipal investigator9901884491ullasable@gmail.com