Combined Spin- and Gradient-Echo Perfusion Weighted Imaging for Characterizing Vascular Architecture of Brain Lesions
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Measurement of perfusion parameter: cerebral blood volume (CBV)
研究概览
简要总结
The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast.
排除标准
- •Subject or subject's legally authorized representative is unable or unwilling to consent to the study.
- •Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.
研究组 & 干预措施
Diagnostic (DSC MRI)
干预措施: Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) (Diagnostic Test)
结局指标
主要结局
Measurement of perfusion parameter: cerebral blood volume (CBV)
时间窗: Baseline to end of study (up to 2 years)
Measurements of cerebral blood volume (CBV) will be calculated.
Measurement of perfusion parameter: vessel size index (VSI)
时间窗: Baseline to end of study (up to 2 years)
Measurements of vessel size index (VSI) will be calculated.
次要结局
未报告次要终点