Arterial Spin Labeling Perfusion Magnetic Resonance (MR) Imaging in Pediatric Brain Tumors
- Conditions
- Brain Tumors
- Registration Number
- NCT00907244
- Lead Sponsor
- Children's Hospital of Philadelphia
- Brief Summary
The purpose of this study is to get information regarding the usefulness and accuracy of this new magnetic resonance imaging (MRI) technique - termed arterial spin labeling (ASL) - in the diagnosis of pediatric brain tumors.
- Detailed Description
The purpose of this study is to get information regarding the usefulness and accuracy of this new MRI technique - termed arterial spin labeling (ASL) - in the diagnosis of pediatric brain tumors. This technique can non-invasively measure the blood flow to the brain during MRI examination. Because aggressive brain tumors require new blood vessels and a high level of blood supply to support its growth, we believe the tumor blood flow measured using ASL is a reliable indicator of tumor grade. This information may be useful for doctors to make treatment decisions and to monitor patients' response to treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
- Age 0-18 years
- Primary brain tumor (newly diagnosed or recurrent) with measurable disease (at least 1cm2)
- Patients with cardiac pacemaker or ferrous metal foreign bodies
- Patients with medical problems contradictive to receiving MRI scans.
- Patients requiring general anesthesia or sedation for their MRI scan.
- Patients with a history of cerebrovascular disorders (stroke, moya moya) that may alter cerebral perfusion.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States