Effect of Glycopyrrolate and Atropine as Adjuncts to Reversal of Non-Depolarizing Neuromuscular Blocking Agents on Postoperative Catheter-Related Bladder Discomfort
试验速览
- 阶段
- 不适用
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Catheter-related bladder discomfort
研究概览
简要总结
We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.
详细描述
The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The adjuncts to reversal agents such as glycopyrrolate and atropine are known to block the muscarinic receptor in different ways.
We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for transurethral bladder excision under general anesthesia
- •ASA I-III
排除标准
- •Foley catheter less than 18 Fr.
- •Patients with obstruction of urinary tract
- •Patients with neurogenic bladder
- •Patients with severe obesity
- •Patients with neurologic disorder
- •Patients with chronic pain
- •Patients with allergic history to atropine or glycopyrrolate
研究组 & 干预措施
Glycopyrrolate
Glycopyrrolate will be administered as the adjuncts of neuromuscular blocker reversal agent.
干预措施: Glycopyrrolate (Drug)
Atropine
Atropine will be administered as the adjuncts of neuromuscular blocker reversal agent.
干预措施: Atropine (Drug)
结局指标
主要结局
Catheter-related bladder discomfort
时间窗: 1 hour postoperatively
Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
次要结局
- Hemodynamic parameters(0, 1, 5, 10 minute postoperatively)
- Nausea(0, 1, 6 and 24 hour postoperatively)
- Vomiting(0, 1, 6 and 24 hour postoperatively)
- Blurred vision(0, 1, 6 and 24 hour postoperatively)
- Flushing(0, 1, 6 and 24 hour postoperatively)
- Dizziness(0, 1, 6 and 24 hour postoperatively)
- Analgesics(0, 1, 6 and 24 hour postoperatively)
- Catheter-related bladder discomfort(0, 6 and 24 hour postoperatively)
- Dry mouth(0, 1, 6 and 24 hour postoperatively)