Whole Body Vibration Training for Nemaline Myopathy

Phase 2

Recruiting

• Conditions: emaline Myopathy; Nemaline Myopathy; Neurological - Other neurological disorders; Musculoskeletal - Other muscular and skeletal disorders; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders

• Registration Number: ACTRN12613000759796
• Lead Sponsor: The Children's Hospital at Westmead

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Children and adolescents aged between 4 – 18 years with nemaline myopathy.

Exclusion Criteria

Cognitive impairment which would impede the ability of test subjects to comply with testing; 25-hydroxyvitamin D level < 50 nmol/L; Lower limb fracture within the preceding 6 months; Use of a medication known to increase bone mass, eg bisphosphonates.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle function will be assessed through Leonardo Jumping Platform, Isokinetic Cybex dynamometer and the Modified Bruce Protocol Treadmill Test. <br>[Baseline, 6 months after standard therapy and after 3 and 6 months of WBVT];Muscle size will be assessed through Peripheral Quantitative Computer Tomography (pQCT) of non-dominant Tibia and Magnetic Resonance Imaging (non-dominant thigh muscle cross sectional area). <br>[Baseline, 6 months observation and after 6 months WBVT];Bone Measurers assessed through Peripheral Quantitative Computer Tomography (pQCT) of non-dominant Tibia and total body and lumbar spine DXA.[Baseline, 6 months observation and after 6 months WBVT]