Can 5 months of whole body vibration therapy improve muscle function and bone density in adolescents with motor disability?

Completed

• Conditions: Spina Bifida; Motor disability ( muscle-skeletal disability); Genetic/disease motor disorder; Injury related motor disorder; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders; Musculoskeletal - Other muscular and skeletal disorders; Neurological - Other neurological disorders

• Registration Number: ACTRN12615000092594
• Lead Sponsor: Prof Paul Hofman

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-04
• Study Completion: 2018-09-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

adolescents with heterogeneous motor disability that is not cerebral palsy ( GMFCS II-IV) aged between 10-20 years. This would include patients with: mild to moderate spina bifida, genetic/disease motor disorders and injury related motor disorder. To be included in the study participants must be able to stand on the vibration plate ( with or without assistance) and be able to undertake evaluation assessments.

Exclusion Criteria

Participants will be excluded if:1)They have a fracture within 8 weeks of enrolment, pregnancy and acute thrombosis, muscle or tendon inflammation, renal stones, discopathy or arthritis. 2) There is a history of clinically significant organic disease or findings on physical examination, which in the opinion of the Investigator would prevent the patient from completing the study. 3)There is a history of using any of the following medications, regardless of dose, for at least 1 month, within 3 months of enrolment: anabolic agents, glucocorticoids (does not include inhaled glucocorticoids) or growth hormone. Participants will not receive Botulinium toxin injection throughout duration of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone mineral density of non-dominant tibia by Peripheral Quantitative Computer Tomography (pQCT scan)[baseline and 20 weeks after baseline];Body composition assessed by Dual Energy X-Ray Absorptiometry (DEXA scan)[baseline and 20 weeks after baseline]

Secondary Outcome Measures

Name	Time	Method
muscle function assessed by chair rise using the Leonardo mechanography force plate.[baseline and 20 weeks after baseline];Muscle function assessed by jump power using the Leonardo mechanography force plate.[baseline and 20 weeks after baseline];Muscle function assessed by both feet balance and one foot balance using the Leonardo mechanography force plate.[baseline and 20 weeks after baseline];Muscle function assessed by the distance walked in 6 minutes using the 6 minutes walk test.[baseline and 20 weeks after baseline]