Knee joint (in)stability in patients with knee osteoarthritis*
- Conditions
- osteoarthritis10023213
- Registration Number
- NL-OMON47889
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
In order to be eligible to participate the study, a knee osteoarthitis (KOA) subject must meet all of the following criteria:
- Unilateral or bilateral diagnosis of the KOA according to the American college of Rheumatology (ACR) criteria. ACR criteria are age over 50 years, morning stiffness less than 30 minutes, crepitus on active motion, bony tenderness or absence of palpable warmth of synovium.
- Able to walk for 5 minutes without stopping.
- A maximal score of 7 on the numeric scale (NRS) for pain intensity during the past two weeks.
- Body mass index (BMI) between 20 and 35 kg/m2.;The KOA subjects will be assigned to the KOA-I group (group with unstable knees) based on the following criterion:
- Have had the perception of an episode of buckling, shifting or giving way of the knee in the past 4 weeks based on questionnaire (KOS-ADLS).;The KOA subject will be assigned to the KOA-S group (group with stable knees) based on the following criterion:
- Have had no perception of an episode of buckling, shifting or giving way of the knee in the past 3 months on questionnaire (KOS-ADLS).;Healthy controls will be age matched, gender matched and BMI matched with the total KOA group (i.e. similar mean ± standard deviation as total KOA group, except for gender which will be about the same ratio as the total KOA group (+- 3%)).
Potential KOA subject meeting any of the following criteria will be excluded from participation in the study:
- Diagnosed with hip osteoarthritis, rheumatoid arthritis or any other form of inflammatory arthritis (i.e., septic arthritis, crystal arthropathy)
- Has a lower extremity joint replacement.
- Has had a knee related injury last year.
- Not signed an informed consent.;A potential control subject meeting any of the following criteria will be excluded from participation in the study:
- Diagnosed with a musculoskeletal disease.
- Has a lower extremity joint replacement.
- Has had a knee related injury last five years.
- Has knee-related problems.
- Not signed an informed consent.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcomes of the study are the responses of the gait kinematics,<br /><br>gait kinetics and EMG signals (of the main muscles spanning the knee joint)<br /><br>during and after mechanical perturbations.The responses of the subjects forms<br /><br>the basis for the development of the dynamic stability measure (GSN). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes of the study are self-reported knee joint instability (Knee<br /><br>Outcome Survey (KOS) and Knee disability and Osteoarthritis Outcome Score<br /><br>(KOOS)), postural balance, self-reported functional ability (Western Ontario<br /><br>and McMaster Universities Arthritis Index (WOMAC), functional performance tests<br /><br>(Get Up and Go test (GUG), 10-meter walk test), knee joint proprioception,<br /><br>Varus * Valgus laxity, muscle strength (HUMAC NORM isokinetic knee test) and<br /><br>disease severity (Kellgren and Lawrence grade (K&L)). </p><br>